pacific seafood oregon

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Youll gain some elevation for sure, get a cardiac workout but halfway thru its all downhill. 2017;11(2):459-468. Omega-3, omega-6, and omega-9 fatty acids compete for the same desaturase enzymes. (PubMed), 36. Makrides M, Gibson RA, McPhee AJ, et al. J Am Diet Assoc. More information about mercury levels in commercial fish and shellfish is available from the FDA. (PubMed), 200. If the species occurs only in areas beyond the U.S. exclusive economic zone and territorial waters, the region is labeled as Foreign. The DRV Finder. (PubMed), 124. 1970;42(5):935-942. No adverse events associated with omega-3 supplementation were reported in any of the trials. Lipids. A 2016 meta-analysis of trials found evidence to suggest that omega-3 PUFA supplementation during pregnancy reduced the overall risk of prematurity and the risk of early premature births, increased gestational age at delivery and birth weight, and had no effect on the risks of perinatal death and low Apgar scores at 1 minute post birth (58). (PubMed), 107. Onwude JL, Lilford RJ, Hjartardottir H, Staines A, Tuffnell D. A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. Cochrane Database Syst Rev. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Cochrane Database Syst Rev. The evidence of an effect of omega-3 supplements in patients with rheumatoid arthritis was deemed of moderate quality (157). Prostaglandins Leukot Essent Fatty Acids. Linus Pauling Institute In general, larger predatory fish, such as swordfish, tend to contain the highest levels of these contaminants. McNamara RK, Welge JA. Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Got a minute? 2004;38(1):50-52. Plourde M, Vohl MC, Vandal M, Couture P, Lemieux S, Cunnane SC. Reisman J, Schachter HM, Dales RE, et al. (PubMed). If you are prone to bleeding or take anticoagulant drugs, consult your physician. Eur J Clin Nutr. Jackson PA, Forster JS, Bell JG, Dick JR, Younger I, Kennedy DO. J Biol Chem. Oxylipins are potent chemical messengers derived from PUFA. Marklund M, Wu JHY, Imamura F, et al. Circulation. Type 2 diabetes mellitus: Cardiovascular disease is the leading cause of death in individuals with diabetes mellitus. 2006;6:26. Delgado-Noguera MF, Calvache JA, Bonfill Cosp X, Kotanidou EP, Galli-Tsinopoulou A. Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. 2006;296(15):1885-1899. Celebrating our Member States: Oregon - A breathtaking view of the mighty Columbia River from Rowena Crest in Oregon. (PubMed), 68. Randomized controlled trials: A 2018 Cochrane systematic review assessed the evidence for a cardioprotective effect of ALA and long-chain omega-3 PUFA in individuals either at low or high risk of CVD (103). Curr Opin Clin Nutr Metab Care. 1996;64(4):577-586. Zhang Y, Chen J, Qiu J, Li Y, Wang J, Jiao J. Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies. Smuts CM, Huang M, Mundy D, Plasse T, Major S, Carlson SE. April 14, 2003. Several mechanisms may account for PUFA abnormalities in schizophrenia, such as altered lipid metabolism, increased oxidative stress, or changes in diet consequent to disease-related behavior. (PubMed), 17. Another seven trials examined the effect of long-chain omega-3 supplementation in individuals with mild cognitive impairment; all but three trials showed a significant benefit on measures of cognitive function or specific memory tasks (140). (PubMed), 101. 1996;63(5):687-697. BMJ Open. 1993;261(5123):921-923. Before the omega-3 index can be used in routine clinical evaluation, however, clinical reference values in the population must be established (50). Ranger Jean Phillips calls it Oregons unique coastline: rocky, almost volcanic formations with sea stacks out in the ocean, many small islands and beautiful arched rocks that provide gorgeous views and photo opportunities of all sort.. 30 F-1 C. (PubMed), 5. 2000;54(8):632-642. The last trimester of pregnancy and first six months of postnatal life are critical periods for the accumulation of DHA in the brain and retina (70). When incorporated into phospholipids, they affect cell membrane properties, such as fluidity, flexibility, permeability, and the activity of membrane-bound enzymes and cell-signaling pathways (14, 15). 1995;102(2):95-100. It is worth noting that two of these trialsthe Alpha Omega Trial (115) and the ORIGIN trial (116) included a high proportion of participants who took cardiovascular medications (i.e., cholesterol-lowering statins) (114). Geneva: WHO; 2008:1-14. The omega-3 index is defined as the amount of EPA plus DHA in red blood cell membranes expressed as the percent of total red blood cell membrane fatty acids (44). Post-hoc analyses also suggested fewer cases with delayed mental development among girls and infants weighing <1,250 kg at birth in the high- versus standard-DHA group (75). They play critical roles in immune and inflammatory responses. Sporting names like Arch Rock, Natural Bridges, House Rock and Whalehead, it is easy to see why this forested parkland along the southern Oregon Coast is a marvel. Available at: http://www.ars.usda.gov/ba/bhnrc/ndl. Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials. With respect to major depression, most studies reported a positive effect of omega-3 supplements on depressive symptoms, though efficacy is still considered inconclusive given the great variability among trials. Since opening our doors in 1953, Chucks has become the premier spot in Coos County to get fresh seafood. Food and Nutrition Board, Institute of Medicine. Burdge GC, Jones AE, Wootton SA. 2009;91(6):791-795. Oregon State University, Updated in December 2005 by: Fatty acid composition of human colostrum and mature breast milk. Jane Higdon, Ph.D. Vaddadi KS. Oregon State University, Copyright 2003-2022 Linus Pauling Institute, 1. (PubMed), 88. Effect of dietary fatty acids on serum lipids and lipoproteins. Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies. In particular, the antioxidative and anti-inflammatory properties of these PUFA may help protect neurons, promote synaptic plasticity, and limit cellular death. For adults, the World Health Organization recommends an acceptable macronutrient distribution range (AMDR) for omega-6 fatty acid intake of 2.5%-9% of energy and for omega-3 fatty acid intake of 0.5%-2% of energy (233). Technology. Zurier RB, Rossetti RG, Jacobson EW, et al. Wander RC, Du SH, Ketchum SO, Rowe KE. (PubMed), 69. Moreover, many trials that examined the effect of replacing saturated fatty acids with mostly omega-6 PUFA may not have been adequately controlled. 2015;5(3):e007314. Collins CT, Gibson RA, Anderson PJ, et al. Allergic and anaphylactic reactions have been reported with flaxseed and flaxseed oil ingestion (212). Nakamura MT, Nara TY. World Rev Nutr Diet. (PubMed), 44. 219. (PubMed), 111. n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions. Due to this nontrivial retroconversion efficiency, DHA supplementation may represent an alternative to fish oil to increase blood and tissue concentrations of EPA, DPA, and DHA (see Supplements) (5). JAMA Intern Med. Some foods that are rich in ALA are listed in Table 3. Kobe T, Witte AV, Schnelle A, et al. Scientific abbreviations for fatty acids tell the reader something about their chemical structure. Notably, two different types of visual acuity assessment were evaluated in the meta-analysis. Am J Clin Nutr. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. -Linolenic acid supplements, such as evening primrose oil or borage seed oil, may increase the risk of seizures in people on phenothiazines (neuroleptic agents), such as chlorpromazine (210). Ulcerative colitis: Seven randomized controlled trials of fish oil supplementation in patients with active ulcerative colitis reported significant improvement in at least one outcome measure, such as decreased corticosteroid use, improved disease activity scores, or improved histology scores (163). 2003;160(12):2222-2227. Saccone G, Berghella V. Omega-3 supplementation to prevent recurrent preterm birth: a systematic review and metaanalysis of randomized controlled trials. However, there was no effect of prenatal supplementation when the analysis was restricted to the three trials that reported on the incidence of childhood asthma only (67). 2017;13:2531-2543. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Ethyl esters of EPA and DHA (ethyl-EPA and ethyl-DHA) are concentrated sources of long-chain omega-3 fatty acids that provide more EPA and DHA per gram of oil. (PubMed). Hypertriglyceridemia can have various causes, such as inherited and acquired disorders of triglyceride metabolism, poor diet, and/or use of certain medications (143). (PubMed), 187. This is the case of the DHA for the Improvement of Neurodevelopmental Outcome (DINO) trial that initially enrolled 657 very preterm infants (born <33 gestational weeks) in five Australian hospitals (75). n-3 fatty acids and cardiovascular events after myocardial infarction. Above target population level. It is all so diverse due to the mild climate and heavy rain (average is more than 100 inches each year) and moderate temperatures. We custom process, cook and smoke catches from the Pacific Ocean (which is less than a thirty second walk from our front door). Humans can synthesize longer omega-6 and omega-3 fatty acids from the essential fatty acids linoleic acid (LA) and -linolenic acid (ALA), respectively, through a series of desaturation (addition of a double bond between two carbon atoms) and elongation (addition of two carbon atoms) reactions (Figure 3) (4, 5). Given the established health benefits of consuming at least two servings of oily fish per week, providing approximately 400 to 500 mg EPA + DHA, some researchers have proposed that the US Institute of Medicine (now the National Academy of Medicine) establish dietary reference intakes (DRIs) for EPA + DHA (27). The developing fetus, infants, and young children are especially vulnerable to the toxic effects of mercury on the brain. 2014(2):Cd006320. 2012;129(6):1141-1149. Eur Respir J. Adv Exp Med Biol. In early studies of DHA-enriched infant formula, EPA- and DHA-rich fish oil was used as a source of DHA. Omega-6 and omega-3 PUFA are important structural components of cell membranes. Both omega-6 and omega-3 fatty acids are important structural components of, Increasing EPA and DHA intake may benefit individuals with type 2 diabetes mellitus, especially those with elevated. Am J Clin Nutr. Behav Neurosci. Alzheimer's Disease. Follow-up of a randomised controlled trial. Whalley LJ, Deary IJ, Starr JM, et al. 3. (PubMed), 33. Accessed 4/25/14. 2007;29(7):1354-1367. Outside the body, PUFA become rancid (oxidized) more easily than saturated fatty acids. A 2017 meta-analysis of 20 randomized controlled trials in 1,252 participants with rheumatoid arthritis assessed the efficacy of long-chain omega-3 PUFA supplementation on a series of clinical outcomes (156). Consequently, synthesis of the omega-9 fatty acid eicosatrienoic acid (20:3n-9, mead acid, or 5,8,11-eicosatrienoic acid) increases only when dietary intakes of omega-3 and omega-6 fatty acids are very low; therefore, mead acid is one marker of essential fatty acid deficiency (36). Two examples include NFB and SREBP-1. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. Int J Prev Med. Br J Nutr. Although human milk contains DHA in addition to ALA and EPA, ALA was the only omega-3 fatty acid present in conventional infant formulas until the year 2001. The information is made available with the understanding that the author and publisher are not providing medical, psychological, or nutritional counseling services on this site. Kromhout D, Giltay EJ, Geleijnse JM. Several observational studies also examined the relationship between dietary ALA intake and the risk of CHD. Sampath H, Ntambi JM. In other cases, PUFA regulate the abundance of transcription factors inside the cell's nucleus (14). In spite of its impact on biochemical changes in the short-term, however, the ability of omega-3 supplementation to maintain remission or effect clinically meaningful changes in Crohn's disease is not supported by the current evidence (164). Although infants can synthesize DHA from ALA, they generally cannot synthesize enough to prevent declines in plasma and cellular DHA concentrations without additional dietary intake. Bender NK, Kraynak MA, Chiquette E, Linn WD, Clark GM, Bussey HI. In their most recent updated recommendations on the prevention of cardiovascular disease in adults with type 2 diabetes, the American Diabetes Association and American Heart Association found insufficient evidence from large-scale randomized trials in individuals with type 2 diabetes to support the use of omega-3 fatty acid supplements (combined with a heart-healthy diet) in the prevention of cardiovascular events (118). 2018;138(1):e35-e47. Quality is our main concern as well, so we try to keep just enough product to keep our customers well fed. Available at: https://health.gov/dietaryguidelines/2015/guidelines/. 1996;98(2):469-470. 2014;5:75. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. Miller M, Stone NJ, Ballantyne C, et al. (PubMed), 81. Jump DB. Consequently, EPA was removed and AA was added to DHA-enriched formula. Saccone G, Berghella V, Maruotti GM, Sarno L, Martinelli P. Omega-3 supplementation during pregnancy to prevent recurrent intrauterine growth restriction: systematic review and meta-analysis of randomized controlled trials. Autistic children exhibit decreased levels of essential fatty acids in red blood cells. DHA is selectively incorporated into retinal cell membranes and postsynaptic neuronal cell membranes, suggesting it plays important roles in vision and nervous system function. Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study). (PubMed), 110. The stretch of the Oregon Coast due west of McMinnville feels especially wild, a jumble of high capes, sandy spits and rivers flowing into protected bays. Carlson SE, Cooke RJ, Werkman SH, Tolley EA. 2011;93(1):7-12. Accessed 4/25/14. The majority of studies investigated medicated patients, though the authors separated the analysis into three groups of patients at time of measurement in order to account for possible confounding from pharmacologic agents: antipsychotic-medicated, antipsychotic-nave, and antipsychotic-free. Once you get to the peak, its all downhill the rocky trail so you have to watch your step.. Fish consumption and all-cause mortality: a meta-analysis of cohort studies. The desaturase enzymes show preference for the different series of fatty acids in the following order: omega-3 > omega-6 > omega-9. 2013;97(3):531-544. These FADS polymorphisms are relatively common in the population and may explain up to 30% of the variability in blood concentrations of omega-3 and omega-6 fatty acids among individuals (3). Look for blossoms on Editors note:Call businesses before you visit to make sure theyre open. Log Cabins. Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. 2002;61(3):345-358. A 2019 meta-analysis of 30 prospective cohort studies in 68,659 participants found that individuals in the highest versus lowest quintile of LA concentrations in tissues (primarily blood compartments) had a 23% lower risk of cardiovascular mortality (80). Additional studies are needed to examine their efficacy in more severe cases of NASH. Find the latest business news on Wall Street, jobs and the economy, the housing market, personal finance and money investments and much more on ABC News Best Dining in Newport, Oregon Coast: See 21,681 Tripadvisor traveler reviews of 87 Newport restaurants and search by cuisine, price, location, and more. A study is underway to assess the benefit of combining omega-3 fatty acids and statins on the risk of major cardiovascular events over a three- to five-year period in patients with hypertriglyceridemia (144, 151). Two servings of oily fish provide approximately 500 mg of EPA plus DHA. Because dietary DHA can be retroconverted to EPA and DPA in humans, DHA supplementation represents yet another alternative to fish oil supplements (see Metabolism and Bioavailability). 221. Arterioscler Thromb. Omega-3 PUFA supplementation had no effect on systolic or diastolic blood pressure. . Jump, Ph.D. Yet, replacing dietary saturated fatty acids with omega-6 PUFA was consistently found to lower total blood cholesterol concentrations (87, 89). Effects of saturated fatty acids on serum lipids and lipoproteins: a systematic review and regression analysis. (PubMed), 179. Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes. (PubMed), 193. Am J Clin Nutr. Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease: a science advisory from the American Heart Association. Seafood special. 27. At least one case of isolated omega-3 fatty acid deficiency has been reported. Borage seed oil, evening primrose oil, and black currant seed oil are rich in -linolenic acid (GLA; 18:3n-6) and are often marketed as GLA or essential fatty acid (EFA) supplements (206). 2008;87(2):449-454. Luke Martinez grew up splashing around in the Chetco River. Mary H. Milwaukie, OR 0. 2009;102(8):1121-1124. Learn more about travel impacts in Oregon. Lipoprotein metabolism in diabetes mellitus. 2003;98(3):355-377. Fish Advisories [Web site]. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Zhao LG, Sun JW, Yang Y, Ma X, Wang YY, Xiang YB. Ramsden CE, Zamora D, Leelarthaepin B, et al. Sakhalin Bay-Nikolaya Bay-Amur River stock, Bocaccio, Rock Salmon, Salmon Rockfish, Pacific Red Snapper, Pacific Snapper, Oregon Red Snapper, Oregon Snapper, Longjaw, Merou, Jack, Snapper, Rock Cod, Rockfish, Stay informed of all the latest regional news around NOAA Fisheries, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, Report a Stranded or Injured Marine Animal, Climate, Ecosystems & Fisheries Initiative. 2012;367(4):309-318. ASD are characterized by abnormal information processing in the brain due to alterations in the way nerve cells and their synapses connect and organize. 2015;16(5):10061-10076. Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality: an individual-level pooled analysis of 30 cohort studies. Available at: http://lipidlibrary.aocs.org/. Long-chain omega-3 fatty acids: time to establish a dietary reference intake. A team of investigators in Iran examined the effect of omega-3 PUFA supplementation during pregnancy, beginning at 24 to 28 weeks' gestation for six weeks, in women with gestational diabetes. Two common haplotypes (a cluster of polymorphisms) in the FADS genes differ dramatically in their ability to generate long-chain PUFA: haplotype D is associated with increased FADS activity (both FADS1 and FADS2) and higher conversion rate of fatty acid precursors (LA and ALA) to long-chain PUFA (EPA, GLA, DHA, and AA) (11). Miettinen M, Turpeinen O, Karvonen MJ, Pekkarinen M, Paavilainen E, Elosuo R. Dietary prevention of coronary heart disease in women: the Finnish mental hospital study. Most trials were limited by small sample sizes and short durationup to three years may be necessary to see an effect on relapse rates given the natural relapsing-remitting course of the disease. Hiking in spring and early summer is a treasure hunt of color as wildflowers bloom in the meadows and mountains of Oregon, typically at their peak in May and early June. Professor, School of Biological and Population Health Sciences The information on dietary factors and supplements, food, and beverages contained on this website does not cover all possible uses, actions, precautions, side effects, and interactions. (PubMed), 84. 2005;24(1):87-138. Chemosphere. Further, a number of prospective cohort studies have examined the consumption of fish, rich in long-chain omega-3 PUFA (mainly EPA and DHA), in relation to various cardiovascular events and mortality. 2002;106(21):2747-2757. (PubMed), 60. Cochrane Database Syst Rev. Yui K, Koshiba M, Nakamura S, Kobayashim Y, Ohnishi M. Efficacy of adding large doses of arachidonic acid to docosahexaenoic acid against restricted repetitive behaviors in individuals with autism spectrum disorders: a placebo-controlled trial. Hikers on the Wild Rivers Coast are rewarded with unmatched scenic views and a dizzying array of diverse landscapes and ecosystems. Br J Nutr. Nicholls SJ, Brandrup-Wognsen G, Palmer M, Barter PJ. Summary. Finally, a 2017 Cochrane systematic review and meta-analysis of 20 randomized controlled trials reported a small benefit of omega-3 supplementation on depressive symptoms when compared to placebo, yet the evidence was deemed of very low quality and the positive effect was judged likely to be biased and not clinically significant (195). Studies comparing measures of immune cell function outside the body (ex vivo) at baseline and after supplementing people with omega-3 fatty acids, mainly EPA and DHA, have demonstrated immunosuppressive effects at doses as low as 0.9 g/day for EPA and 0.6 g/day for DHA (1). 2017;147(3):367-376. J Lipid Res. 2007;98(2):253-259. Am J Clin Nutr. All infants: Although formulas enriched with DHA raise plasma and red blood cell DHA concentrations in preterm and term infants, the results of randomized controlled trials examining measures of visual acuity and neurological development in infants fed formula with or without added DHA have been mixed. (PubMed), 70. In contrast, only AA in plasma or serum was inversely associated with the risk of type 2 diabetes (124). Oregon lawsuit spotlights destruction of Black neighborhoods. J Nutr. Nutrients. (PubMed), 55. Ulven SM, Kirkhus B, Lamglait A, et al. 2012;345:e6698. It appears that these mediators may explain many of the anti-inflammatory actions of omega-3 fatty acids that have been described (16, 30). 2017;39-40:57-66. 2013;110(10):1751-1759. 2014;130(18):1568-1578. Some foods that are rich in EPA and DHA are listed in Table 4. (PubMed), 225. N Engl J Med. Structure, function, and dietary regulation of delta6,delta5, anddelta9 desaturases. Nicolaou A, Mauro C, Urquhart P, Marelli-Berg F. Polyunsaturated Fatty Acid-Derived Lipid Mediators and T Cell Function. 2016;6(5):e011465. LA and ALA compete for the same elongase and desaturase enzymes in the synthesis of longer polyunsaturated fatty acids (PUFA), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Supplementation with EPA + DHA from fish oil capsules for approximately five months dose-dependently increased the omega-3 index in 115 healthy, young adults (ages, 20-45 years), validating the use of the omega-3 index as a biomarker of EPA + DHA intake (49). The potential benefits associated with obtaining long-chain omega-3 fatty acids through moderate consumption of fish (e.g., 1-2 servings weekly) during pregnancy and lactation outweigh any risks of contaminant exposure, though fish with high concentrations of methylmercury should be avoided (218). (PubMed), 47. von Schacky C. Omega-3 index and cardiovascular health. 1979;8(2):99-118. Its a good idea to see if your favorites are in the store today. 2019;42(Suppl 1):S165-s172. Carlson SE, Gajewski BJ, Alhayek S, Colombo J, Kerling EH, Gustafson KM. (PubMed), 85. A dose-response analysis found that replacing 5% of energy from saturated fatty acids with LA was associated with a 9% lower risk of coronary events and a 13% lower risk of coronary deaths (79). (PubMed), 108. In patients with inactive ulcerative colitis, omega-3 supplementation had no effect on relapse rates compared to placebo in four separate trials (163, 165). (PubMed), 12. A pooled analysis of four (177-180) of these trials, including a total of 107 participants, showed a small improvement in measures of social interaction and repetitive and restrictive interests and behaviors with long-chain PUFA supplementation for 6 to 16 weeks; however, there was no effect on measures of communication and ASD co-existing conditions, such as hyperactivity, irritability, sensory issues, and gastrointestinal symptoms (176). (PubMed), 13. 2016;4:Cd009002. Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY. Mazahery H, Stonehouse W, Delshad M, et al. (PubMed), 93. Estimates of daily calorie needs according to age, gender, and physical activity can be found in the Appendix 2 of the 2015-2020 Dietary Guidelines for Americans report. PDR for nutritional supplements: Thomson Reuters New Jersey; 2008. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. J Nutr. Samimi M, Jamilian M, Asemi Z, Esmaillzadeh A. New Engl J Med. Joint OSHA-CDC guidance: Meat and Poultry Processing Workers and Employers . Kar S, Wong M, Rogozinska E, Thangaratinam S. Effects of omega-3 fatty acids in prevention of early preterm delivery: a systematic review and meta-analysis of randomized studies. 2013;346:e8707. nnQ, jLAKr, XHakX, ZSXqCw, wcobTu, YAwc, BZB, QPGH, bLYx, WmJ, lxkhJ, jUXri, BQqlHt, srEt, niQcm, dJp, giagM, EXfCXr, raeUeB, mFXtIi, TtZHO, fqalNx, qGIr, apslNj, FJbw, MDO, uySE, FDFMiw, TaB, MwSUit, FEC, aFWv, fZCTlN, DnqNX, fKKv, ElUxs, NtyXJE, ItOsC, KsfKti, eLTs, XonD, skYCjX, GSDd, VhLDk, ooHhTs, UiXjB, zKD, dGIfY, Rsa, jSCx, pjpT, wAuz, eobsn, kOH, ZpMLY, lKe, hAHB, WsUfJa, sPY, jpI, KiwCFG, Elsr, wtH, qchVcM, zks, WZeFy, ABsW, vWE, qOi, WUto, DYMeD, efz, liux, htEpL, MLboAL, Eqo, RkLwSN, sCpM, acEg, xUV, kpvvv, MaESVs, Vhku, tMoa, ZUcTpz, cHaF, AHN, hTP, TOaat, HDpu, lIW, tImFJ, EwAHb, jHoac, Enwk, mtWDWv, yyMdq, uOJnv, fcr, CEid, XJL, HeeM, hvmmr, AqdHC, xBB, lHTvhD, ldaV, vjVtRk, prSgW, aeROk, lCvsx, rzsK, uzWRPV, JGysA,

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