Real progress has been made in the last 10 years, providing pharmaceutical scientists with a solid basis for understanding the interaction of water with solids of pharmaceutical interest. [36], The fact that the prostate was one and not two organs was an idea popularised throughout the early 18th century, as was the English language term used to describe the organ, prostate,[36] attributed to William Cheselden. 20. Pharm. Normalizing based on the total moisture present overstates the amount of water available to react and underestimates the actual reaction rate. [4][37] John E. McNeal first proposed the idea of "zones" in 1968; McNeal found that the relatively homogeneous cut surface of an adult prostate in no way resembled "lobes" and thus led to the description of "zones". "We welcome cooperation with interested partners in studying the bioactivities of the bi- and tri-flavones. | Suppliers Starch glycolates are of rice, potato, wheat or corn origin. Make the best use of Researched information from 700+ peer reviewed, Open Access Journals operated by 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and [1][4] The zones are: The "lobe" classification describes lobes that, while originally defined in the fetus, are also visible in gross anatomy, including dissection and when viewed endoscopically. [3], The prostate secretes fluid which becomes part of semen. J. Pharm. Select the correct answer and click on the Finish buttonCheck your score and answers at the end of the quiz, Visit BYJUS for all Biology related queries and study materials, Your Mobile number and Email id will not be published. Digested solids, known also as sludge, is dried and used as fertilizer. Ind. Case III behaviour is an example of the effect of moisture on the progress of the Malliard reaction for the glucose-containing formulations of -N-acetyl-L-lysine, poly-L-lysine, insulin, casein, and plasma proteins, Where dM/dt is the rate of drug loss, k is a rate constant appropriate for the order of the reaction, S is the saturation concentration of the drug in the layer, and (H, The degradation of aspirin powder after 120 days at 100% RH and 25, Finally, the complicated situation faced when a moisture sensitive drug is combined with an hydrophilic excipient is shown in Fig. [18] Ejaculation is the expulsion of semen from the urethra. In addition to the mass production of fermented foods and drinks, industrial fermentation has widespread applications in chemical industry. Harkins, W.D. The surgery most often used in such cases is transurethral resection of the prostate,[25] in which an instrument is inserted through the urethra to remove prostate tissue that is pressing against the upper part of the urethra and restricting the flow of urine. The polar (organic acid) carboxyl groups render the cellulose soluble and chemically reactive. [according to whom?] Wu, Y.C. Also Read- Digestion process in Ruminants. Glutamate is produced by some Micrococcus species,[12] and some Corynebacterium species produce lysine, threonine, tryptophan and other amino acids. [16] Around the end of the third month of embryonic life, outgrowths arise from the prostatic part of the urethra and grow into the surrounding mesenchyme. 10. Medical grade and non-toxic. The prostate is a gland of the male reproductive system.In adults, it is about the size of a walnut, and has an average weight of about 11 grams, usually ranging between 7 and 16 grams. ; Bogdanowich, S.J. Detailed guidance, regulations and rules [11] If the biomass is to be used for inoculation of other fermentations, care must be taken to prevent mutations from occurring. Due to their complex structures, it is also challenging to synthesize these molecules. [31] If a tumour is confirmed, medical imaging such as an MRI or bone scan may be done to check for the presence of tumour metastases in other parts of the body. To function properly, the prostate needs male hormones (androgens), which are responsible for male sex characteristics. Pharm. SSP vision is to provide highly energy efficient and cost effective Projects/Equipment for Dairy, Food and Beverage industries across the globe through development of latest technologies through Innovation Centre. Some bacteria, such as Lactobacillus species, are able to produce bacteriocins which prevent the growth of bacterial competitors as well. 1. ; Groves, M.J. Drug Dev. The applications of enzymes include: In the modern world through biotechnology enzymes used in the food industry are extracted directly from the plants and animal sources and are also obtained by microbial fermentation. Drug Dev. 1983, 14, 243. These result demonstrate many of the points presented here. J. Pharm. BARIUM CHLORIDE DIHYDRATE ( ACS GRADE HIGHEST PURITY CHEMICAL GRADE) CALCIUM FORMATE (TECHNICAL GRADE) CALCIUM SULPHATE DIHYDRATE (FOOD GRADE) Acetic Acid 15-20% Weed Killer . Click Start Quiz to begin! [33] General complications due to surgery can also develop, such as infections, bleeding, inadvertent damage to nearby organs or within the abdomen, and the formation of blood clots. Prostatitis is inflammation of the prostate gland. When all the reactant has been solubilized and further water dilutes the medium. Supplementation experiments involve evaluating the effects of nitrogen and carbon supplements on production. Soc. VOLUME 4(6) November - December 2013. In comparison with the few spermatozoa expelled together with mainly seminal vesicular fluid, those in prostatic fluid have better motility, longer survival, and better protection of genetic material. Minimally invasive procedures include transurethral needle ablation of the prostate and transurethral microwave thermotherapy. Enzyme molecules are highly specific to the substrates and convert them into products. Pharmaceutical form. PHARMANEST - An International journal of Advances in Pharmaceutical Sciences. [68][69] Although it is homologous to the male prostate (developed from the same embryological tissues),[70][71] various aspects of its development in relation to the male prostate are widely unknown and a matter of research. [30] Often, a person does not have symptoms; when they do occur, symptoms may include urinary frequency, urgency, hesitation and other symptoms associated with BPH. [16], Precision fermentation is an approach to manufacturing specific functional products which intends to minimise the production of unwanted by-products through the application of synthetic biology, particularly by generating synthetic "cell factories" with engineered genomes and metabolic pathways optimised to produce the desired compounds as efficiently as possible with the available resources. Alipay 33. The addition of the solid humectant sorbitol reduced the reaction rate dramatically by decreasing free water for mobilization of reactants. ; DeVincentis, J. Between 6% and 25% water, the properties of bound water change dramatically, above 25% water, the properties of bound water are similar to bulk water. [2] The prostate is located in the pelvis. cotton or viscose rayonmay also be converted into CMC. Secondary metabolites are compounds made in the stationary phase; penicillin, for instance, prevents the growth of bacteria which could compete with Penicillium molds for resources. There are approximately 1300 different enzymes found in human cells, which include amylase, pepsin, trypsin, pancreatic lipase, ribonuclease and deoxyribonuclease. ", "The human proteome in prostate The Human Protein Atlas", "Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer", "Emerging roles of human prostatic Acid phosphatase", "Prostate-induced orgasms: A concise review illustrated with a highly relevant case study", "Real-time magnetic resonance imaging (MRI): anatomical changes during physiological voiding in men", "Contraction of the anterior prostate is required for the initiation of micturition", "Do patients have to choose between ejaculation and miction? This phase, where the increase of the rate of growth is checked, is the deceleration phase. All these enzymes are involved in the different chemical processes such as the breakdown of large starch molecules, proteins, fats and other nucleic acids. If all of the nutrients in the medium are consumed, or if the concentration of toxins is too great, the cells may become senescent and begin to die off. In the pharmaceutical industry, starch is also used as an excipient, as tablet disintegrant, and as binder. They are also working to expand the scope of the food grade synthetic reaction to synthesize oligomers of other polyphenolic compounds. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as well as with other compounds.Oxygen is Earth's most abundant element, and after hydrogen and helium, it is the third-most abundant element in the [9], Growth factors and trace nutrients are included in the fermentation broth for organisms incapable of producing all of the vitamins they require. Inflammation of the prostate can cause painful urination or ejaculation, groin pain, difficulty passing urine, or constitutional symptoms such as fever or tiredness. [51] The prostate glands of male marsupials are proportionally larger than those of placental mammals. Fungi have been employed to break down cellulosic wastes to increase protein content and improve in vitro digestibility. 9Effect of humidity on the salicylic acid content in aspirin-disintegrant mixtures at 120 days and 250C. [25], Acute prostatitis and chronic bacterial prostatitis are treated with antibiotics. These can potentially be used as active ingredients or pharmaceutical agents to fortify foods, produce nutritional supplements and treat diseases. Get 247 customer support help when you place a homework help service order with us. J. Pharm. 1989, 13 (4 -5), 653. First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. For instance, some cultures will not produce secondary metabolites in the presence of phosphate. Disorders of the prostate include enlargement, inflammation, infection, and cancer. DOI: 10.1038/s41467-022-34123-w, Journal information: High levels of transparency which improves the aesthetics of the product. Terms of Use External beam radiotherapy became more popular as stronger X-ray radiation sources became available in the middle of the 20th century. In the production of wine, the medium is grape must. ; Plenum Press: New York, 1992. Thermoplastic starch represents the most widely used bioplastic, constituting about 50 percent of the bioplastics market. [3] Vessels of the prostate itself also drain into the obturator and sacral lymph nodes.[3]. Privacy Policy The first treatments of prostate cancer were surgeries to relieve urinary obstruction. [33][34] Ejaculation of semen will not occur during orgasm if the vas deferens are tied off and seminal vesicles removed, such as during a radial prosatectomy. In addition to the mass production of fermented foods and drinks, industrial fermentation has widespread applications in chemical industry. At the other extreme (20%RH), the analysis is also biased by overstating the amount of water available, but for a different reason. Although many parameters have been tested for use as scale up criteria, there is no general formula because of the variation in fermentation processes. [26], An enlarged prostate is called prostatomegaly, with benign prostatic hyperplasia (BPH) being the most common cause. [6] Insect cell culture systems came into use in the 2000s as well.[13]. 1982, 6 (10), 48. The main disadvantage of bacterial digestion in sewage disposal is that it is a very slow process. Industrial fermentation is the intentional use of fermentation in manufacturing products useful to humans. part may be reproduced without the written permission. At 100%RH, the reaction rate is lower than that expected for croscarmellose and sodium starch glycolate, because the disintegrants swelled and in doing so diminished the available moisture. Ed. [6] The largest difference between this process and the others is that the cells must be ruptured (lysed) at the end of fermentation, and the environment must be manipulated to maximize the amount of the product. One of the difficulties associated with a thermodynamic treatment of solids is the problem of dealing with changes in surface area as a continuous variable. Where dM/dt is the rate of drug loss, k is a rate constant appropriate for the order of the reaction, S is the saturation concentration of the drug in the layer, and (H2 O) is the concentration of water. Fig. These drugs specifically bind to the target and also have an incomparable potential and advantages compared to ordinary small molecular drugs. The total amount of biomass may not decrease, but the number of viable organisms will decrease. Solid organic matters are broken down into harmless, soluble substances and carbon dioxide. [17] Precision fermentation of genetically modified microorganisms may be used to manufacture proteins needed for cell culture media,[18] providing for serum-free cell culture media in the manufacturing process of cultured meat. Functional anatomy of the cetacean reproductive system, with comparisons to the domestic dog. 30. The prostate is a gland of the male reproductive system. Preparation. Ppharmaceutics of Solids and Solid Dosage Forms; Wiley: New York NY, 1977. In glucose-containing systems, it was demonstrated that liquid and solid humectants can influence the mobility of water in the system. [15], The prostatic part of the urethra develops from the middle, pelvic, part of the urogenital sinus, which is of endodermal origin. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across View full aims & scope It works perfectly for any document conversion, like Microsoft Word because of benign prostatic hyperplasia (BPH), damaging or sparing of these two muscle systems varies considerably depending on the choice of operation type and details of the procedure of the chosen technique. This site uses cookies to assist with navigation, analyse your use of our services, collect data for ads personalisation and provide content from third parties. Brittan, H.G. ; Kesselring, U.w. [1] The fibrous tissue separates the gland into lobules. [citation needed]Following the initial reaction, the resultant mixture Enzymes accelerate and change state in chemical reactions. If the layer remains saturated with drug, this approach yields an apparent zero order degradation process given. 1984, 18 (1 2), 99. Stability of Protein Pharmaceuticals; Ahern, T.J., Manning, M.C., Eds. Some examples of primary metabolites are ethanol, citric acid, glutamic acid, lysine, vitamins and polysaccharides. Preparation. Anmol Chemicals Pharmaceutical Excipients, Food Grade Chemicals BP USP IP EP Ph Eur FCC Analytical Reagent Manufacturers. [4][1] Because of the variation in descriptions and definitions of lobes, the zone classification is used more predominantly.[1]. Get weekly and/or daily updates delivered to your inbox. Best Customer Support Service. Prof Huang said, "This reaction was developed from a serendipitous discovery by my doctoral student, Dr. Yang Xin. 13. Departments. googletag.cmd.push(function() { googletag.display('div-gpt-ad-1449240174198-2'); }); Flavonoids are bioactive compounds derived from plants that have a wide range of health promoting benefits. Adv. The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation. 1988, 14, 1891. LACTIC ACID . Tmall Taobao World Lets look at some of its applications below. Furthermore, the product (typically a protein) must be separated from all of the other cellular proteins in the lysate to be purified. Mineral buffering salts, such as carbonates and phosphates, may be used to stabilize pH near optimum. PHARMANEST JOURNAL. ; John Wiley & Sons: NY, 1982. Enzymes are biological catalysts that speed up biochemical reactions. 9Effect of humidity on the salicylic acid content in aspirin-disintegrant mixtures at 120 days and 25 0 C.. One-factor-at-a-time (OFAT) is the preferential choice that researchers use for designing a medium composition. A Comprehensive Study of Water Vapor Sorption by Aspirin-Disintegrant Blends and its Relationship to Aspirin Stability; Ph.D. Thesis, 1982. Password requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; 8. 3. All of these compounds are produced during the normal "business" of the cell and released into the environment. 19. 34. | Int. [7], After a phase of exponential growth, the rate of growth slows down, due to the continuously falling concentrations of nutrients and/or a continuously increasing (accumulating) concentrations of toxic substances. The addition of liquids such as glycerol or propylene glycol lowered the mobilization point and facilitated the reaction at lower humidities. 1988, 14, 1927. Simple starch bioplastic film can be made at home by gelatinizing starch and solution casting. In the history of food, ancient fermented food processes, such as making bread, wine, cheese, curds, idli, dosa, etc., can be dated to more than seven thousand years ago. (Click on Subscription link in your inbox), Production JobsR&D JobsF&D JobsSales & MarketingQA JobsQCJobsFaculty JobsCRO JobsDRA JobsIPR JobsIT JobsPackaging AlertsHospital Pharmacist, D.Pharm AlertsB.Pharm AlertsB.Sc AlertsM.Pharm AlertsM.Sc AlertsMBA AlertsPharm.D AlertsPh.D AlertsMBBS AlertsMD AlertsMS AlertsWalk-in JobsGovernment Jobs, Privacy Policy | Disclaimer | Terms of Use | Advertise | Sitemap | Send Feedback, RECEIVED AWARD AS BEST PHARMA CAREER PORTAL AT ISFCP, Copyright 2008-2022, PharmaTutor Edu Labs, Pharmacy Infopedia, MOISTURE CONTENT: A STABILITY PROBLEM IN PHARMACEUTICAL PRODUCTS, Conventions, Definitions, and Terminology, The result of a TGA of dicalcium phosphate dihydrate is shown in Fig. [citation needed]Following the initial reaction, the resultant mixture Enzymes are used in producing a variety of foods products, beverages processing, animal nutrition, textile industries, household goods, biofuels and other fuels for automobiles, cleaning products and also in energy generation plants. There are approximately 1300 different enzymes found in human cells, which include amylase, pepsin, trypsin, pancreatic lipase, ribonuclease and deoxyribonuclease. Boron is a chemical element with the symbol B and atomic number 5. At 100%RH, the reaction rate is lower than that expected for croscarmellose and sodium starch glycolate, because the disintegrants swelled and in doing so diminished the available moisture. 22. [16] The cells lining this part of the urethra differentiate into the glandular epithelium of the prostate. [19] A 2021 publication showed that photovoltaic-driven microbial protein production could use 10 times less land for an equivalent amount of protein compared to soybean cultivation. [4], At the time, Du Laurens was describing what was considered to be a pair of organs (not the single two-lobed organ), and the Latin term prostatae that was used was a mistranslation of the term for the Ancient Greek word used to describe the seminal vesicles, parastatai;[36] although it has been argued that surgeons in Ancient Greece and Rome must have at least seen the prostate as an anatomical entity. [3], It is possible for some men to achieve orgasm solely through stimulation of the prostate gland, such as via prostate massage or anal intercourse. Shukla, J.; Price, J.C. Pharm. - With the rapid capacity expansion and technology development in recent years, China became a major feed grade amino acid supplier in the world in 2013. In most industrial fermentations, the organisms or eukaryotic cells are submerged in a liquid medium; in others, such as the fermentation of cocoa beans, coffee cherries, and miso, fermentation takes place on the moist surface of the medium. The Collected Works of J. Willard Gibbs; Yale University Press: New Haven, 1948; 1. [50], The prostate is found only in mammals. [according to whom?] 2. Paying attention to details, particularly unexpected results when conducting research, can lead to big discoveries.". In a paper published in Nature Communications, Professor Huang Dejian from the Department of Food Science and Technology, National University of Singapore and his research team developed a catalyst-free method to drive the coupling reaction between flavone monomers to create flavone dimers and oligomers. Pharm. The final experiment is a replacement experiment. For general inquiries, please use our contact form. [32][25] Cancer that has spread to other parts of the body is usually treated also with hormone therapy, to deprive a tumour of sex hormones (androgens) that stimulate proliferation. Growth of the inoculum does not occur immediately. Ben-Rayana, E.; Seddas, A.; Ruelle, P.; Ho, N.T. A common example is ethanol or lactic acid, produced during glycolysis. Industrial fermentation is the intentional use of fermentation in manufacturing products useful to humans. It sits below the urinary bladder and surrounds the urethra. J. Pharm. In its crystalline form it is a brittle, dark, lustrous metalloid; in its amorphous form it is a brown powder. For large scale fermentations, such as those used for the production of ethanol, inexpensive sources of carbohydrates, such as molasses, corn steep liquor,[8] sugar cane juice, or sugar beet juice are used to minimize costs. [17], Condensation of mesenchyme, urethra, and Wolffian ducts gives rise to the adult prostate gland, a composite organ made up of several tightly fused glandular and non-glandular components. At 100%RH, the reaction rate is lower than that expected for croscarmellose and sodium starch glycolate, because the disintegrants swelled and in doing so diminished the available moisture. Carstensen, J.T. In animals, especially in the ruminants or grass-eating animals or herbivores, the cellulase enzymes, existing in their stomach helps to break down the plant cellulose into smaller and easily absorbable nutrients to produce energy for their further metabolic process. Our team believes that the unique bi- and tri-flavones library will contribute to promoting human health and preventing disease," added Prof Huang. Structure. They are generally composed of simple sugars and are often slightly alkaline. The location of the maximum rate of reaction was found to vary from 40% to 80% RH, depending on the additives. Carboxymethyl cellulose is synthesized by the alkali-catalyzed reaction of cellulose with chloroacetic acid. The fact that there can be a maximum degradation rate at a humidity other than 100% RH is observed in other situations as well. However, we do not guarantee individual replies due to the high volume of messages. [3] This network also receives blood from the deep dorsal vein of the penis, and is connected via branches to the vesical plexus and internal pudendal veins. Addition of peroxidase for the colour and nutritional quality of the food. (NYHA grade III or IV) - those at risk of arrhythmia, for example those on treatment for cardiovascular disease or who have thyroid disease Moviprep may result in a potential interactive effect if used with starch-based food thickeners. [28] These outpatient procedures may be followed by the insertion of a temporary stent, to allow normal voluntary urination, without exacerbating irritative symptoms. [33] This will mean a man becomes infertile. Fig. The moisture contents stabilized within the first few days, and the degradation results are presented as moles of the degradation product salicylic acid per mole of water. Blair, T.C. The information you enter will appear in your e-mail message and is not retained by Phys.org in any form. PHARMANEST PUBLICATIONS. We understand the need of the customers, who are under increasing economic competitive and regulatory pressures and partner with them to design and deliver the most reliable, efficient and innovative solutions for the process and overall project implementation. Yeast extract is a common source of micronutrients and vitamins for fermentation media. 1688.com | Affiliate, Product Listing Policy Int. In case I, there is a continual increase in reaction rate with increasing water content above the monolayer. [29], Prostate cancer is one of the most common cancers affecting older men in the UK, US, Northern Europe and Australia, and a significant cause of death for elderly men worldwide. Michael Schnke, Erik Schulte, Udo Schumacher: Rommel, Sentiel A., D. Ann Pabst, and William A. McLellan. cotton or viscose rayonmay also be converted into CMC. ; Extension Servicesin Pharmacy, University of Wisconsin, Madision, 1988; 77,91. Xin Yang et al, Oxygen mediated oxidative couplings of flavones in alkaline water, Nature Communications (2022). If the dilution is extensive, or if water is a product inhibitor of decomposition, a rate reduction can be observed (Case III). about any excipient for pharmaceutical (PDF) Handbook-of-pharmaceutical-excipients-6th-edition.pdf | Benny Wijaya - Academia.edu Academia.edu no longer supports Internet Explorer. Powder for oral solution. Franks, F. Water: A Comprehensive Treatment; Plenum Press: New York, 1972; 1 and 5, 1975. [49] Systemic chemotherapy for prostate cancer was first studied in the 1970s. Pharm. An early thermodynamic treatment to address this problem was presented by Copeland and Young in 1961, The need to address changes in adsorbent is discussed by Zografi, microcrystalline cellulose has been demonstrated by a tableting operation in a very simplistic manner, The literature related to the study of the influence of moisture on the properties and stability of proteins is extensive and growing rapidly. Carstensen presented a theory to describe this non-linear behaviour based on the fact that the formation of salicylic acid actually exposes moisture adsorption sites of higher energy on aspirin35, thereby leading to the acquisition of more water. Organisms meant to produce enzymes such as beta galactosidase, invertase or other amylases may be fed starch to select for organisms that express the enzymes in large quantity. [3] Veins drain into the vesical and then internal iliac veins. Ind. The food-grade synthesis of bi- and tri-flavones. 24. The alkalinity of semen helps neutralize the acidity of the vaginal tract, prolonging the lifespan of sperm. See FAQs on the coronavirus (COVID-19) and Alibaba.com shipments Hydrolases In this experiment all the components of the medium are removed one at a time and their effects on the medium are observed. | Country Search Zografi, G. Drug Dev. Unless other microorganisms contaminate the culture, the chemical constitution remains unchanged. [4][3] The five lobes are the anterior lobe or isthmus, the posterior lobe, the right and left lateral lobes, and the middle or median lobe. VOLUME 5(2) March - April 2014. Luteolin (flavone monomer) is a common flavonoid that exists in many types of plants including fruits and vegetables. 28. "Sinc This explanation accounts for an increase in rate with time, but does not explain why the rate is high for the powder then a suspension where the supply of water is in huge excess. BPH refers to an enlargement of the prostate due to an increase in the number of cells that make up the prostate (hyperplasia) from a cause that is not a malignancy. In general, treatment often begins with an alpha-1 adrenergic receptor antagonist medication such as tamsulosin, which reduces the tone of the smooth muscle found in the urethra that passes through the prostate, making it easier for urine to pass through. 8, Hageman classifies the role of moisture in bimolecular reactions into three cases. In addition, the actual rate of aspirin degradation has been found to increase with time34,35. Ser. 1988, 74 (4), 314. After the deceleration phase, growth ceases and the culture enters a stationary phase or a steady state. Pharm. SSP is a process engineering company offering an extensive range of projects, equipment and innovative process solutions based on advance technology and a real understanding of customer needs in the Food, Dairy, Beverages and Chemical Industries. This method can be separated into some sub groups. 16. PSA values are difficult to interpret, because a high value might be present in a person without cancer, and a low value can be present in someone with cancer. [35][4] Massa described it as a "glandular flesh upon which rests the neck of the bladder," and Vesalius as a "glandular body". More information: Enzymes are involved in various metabolic processes within the cells and the presence of enzymes, helps in faster metabolic activities like sustaining life. Please select the most appropriate category to facilitate processing of your request. 7. - If the dilution is extensive, or if water is a product inhibitor of decomposition, a rate reduction can be observed (Case III).
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