Pi-Sunyer X, Astrup A, Fujioka K, et al. Diabetologia 2020;63:473-485. The interaction effect for FMDBA normalized to peak shear rate was P=0.07. Search authoritative medical information using the FirstSearch MEDLINE interface. The once-weekly 2.4-mg dose of semaglutide was chosen for the present study on the basis of pharmacokinetic modeling that suggested that the 2.4-mg weekly dose had a maximum steady-state concentration similar to a once-daily 0.4-mg dose investigated in a phase 2 dose-finding trial in participants with obesity.14 The results of our study with once-weekly semaglutide at a 2.4-mg dose are consistent with the results of the phase 2 study, which showed an 11.6% greater reduction in body weight with once-daily semaglutide at a dose of 0.4 mg than with placebo after 52 weeks of treatment.14. Targeted plasma metabolomics was performed to gain initial insight into possible circulating factors and pathways involved in the changes in cardiovascular function associated with IMST. Phase 1 only: Regular receipt of inhaled/nebulized corticosteroids. Efficacy and safety of the BNT162b2 mRNA COVID-19 vaccine in participants with a history of cancer: subgroup analysis of a global phase 3 randomized clinical trial. Philosopher's Index is considered the most thorough index of journal literature on the subject and features author-written abstracts covering scholarly research published in journals and books, including contributions to anthologies and book reviews. Faculty and instructors can request from the full collection by using the search feature and within Kanopy requesting it. A method to edit the backbones of molecules allows chemists to modify ring-shaped chemical structures with greater ease. Britannica Online incorporates all articles from the print set with interactive, online features to offer a dynamic online resource: Search education literature and resources using the ERIC EbscoHost interface. (Watch the video below if you doubt this. Fraiman J, Erviti J, Jones M, Greenland S, Whelan P, Kaplan RM, Doshi P. Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. Thomson Reuters Checkpoint, a research service that combines the various types of tax documents into one database. Also Includes archival material. more. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. From the beginning of the pandemic, public health officials agreed that infected people should wear a mask to reduce the likelihood of transmitting the virus to others. A sample size of 1950 participants provided an effective power of 99% for the coprimary and confirmatory secondary end points, tested in a prespecified hierarchical order. Resource is free to all users. Produced by OCLC, the ProceedingsFirst database is updated semimonthly (twice a month). Allometric scaling was used to control for baseline diameter. Percentage of participants in Phase 1 reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], Percentage of participants in Phase 1 reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], Percentage of participants in Phase 1 reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], Percentage of participants in Phase 1 reporting serious adverse events [TimeFrame:From dose 1 through 6 months after the last dose], Percentage of Phase 1 participants with abnormal hematology and chemistry laboratory values [TimeFrame:1 day after dose 1], Percentage of Phase 1 participants with abnormal hematology and chemistry laboratory values [TimeFrame:7 days after dose 1], Percentage of Phase 1 participants with abnormal hematology and chemistry laboratory values [TimeFrame:7 days after dose 2], Percentage of Phase 1 participants with grading shifts in hematology and chemistry laboratory assessments [TimeFrame:Between baseline and 1 day after dose 1], Percentage of Phase 1 participants with grading shifts in hematology and chemistry laboratory assessments [TimeFrame:Between baseline and 7 days after dose 1], Percentage of Phase 1 participants with grading shifts in hematology and chemistry laboratory assessments [TimeFrame:Between before dose 2 and 7 days after dose 2], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], In the first 360 participants randomized into Phase 2/3, percentage of participants reporting serious adverse events [TimeFrame:From dose 1 through 6 months after the last dose], In a subset of at least 6000 participants randomized in Phase 2/3, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], In a subset of at least 6000 participants randomized in Phase 2/3, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], Percentage of participants in Phase 2/3 reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], Percentage of participants in Phase 2/3 reporting serious adverse events [TimeFrame:From dose 1 through 6 months after the last dose], Confirmed COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Percentage of participants 12-15 years of age in Phase 3 reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], Percentage of participants 12-15 years of age in Phase 3 reporting adverse events [TimeFrame:From dose 1 through 6 months after the last dose], In participants 12-15 years of age randomized in Phase 3, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 and dose 2], In participants 12-15 years of age randomized in Phase 3, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 and dose 2], In participants who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting adverse events [TimeFrame:From dose 1 through 1 month after the last dose], In participants who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting serious adverse events [TimeFrame:From dose 1 through 5 or 6 months after the last dose], In participants, who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting local reactions [TimeFrame:For 7 days after dose 1 (and dose 2)], In participants who receive BNT162b2SA given as 1 or 2 doses, percentage of participants reporting systemic events [TimeFrame:For 7 days after dose 1 (and dose 2)], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting adverse events [TimeFrame:From the third dose through 1 month after the third dose], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting serious adverse events [TimeFrame:From the third dose through 6 months after the third dose], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting local reactions [TimeFrame:For 7 days after the third dose], In participants who receive a third dose of BNT162b2 as part of the subset for evaluation of boostability and protection against emerging VOCs, percentage of participants reporting systemic events [TimeFrame:For 7 days after the third dose], In participants who receive a third dose of BNT162b2 as a result of current or anticipated recommendations, percentage of participants reporting adverse events [TimeFrame:From the third dose through 1 month after the third dose], In participants who receive a third dose of BNT162b2 as a result of current or anticipated recommendations, percentage of participants reporting serious adverse events [TimeFrame:From the third dose through 6 months after the third dose], Noninferiority of the SARS-CoV-2 reference strain neutralizing titers after a third dose of BNT162b2 at 30 g compared to after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the third dose], Noninferiority of the SARS-CoV-2 SA strain neutralizing titers after one dose of BNT162b2SA compared to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the third dose], Noninferiority of the SARS-CoV-2 SA strain neutralizing titers after 2 doses of BNT162b2SA compared to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2 [TimeFrame:1 month after the second dose], In Phase 1 participants, SARS-CoV-2 serum neutralizing antibody levels, expressed as GMTs [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, GMFR in SARS-CoV-2 serum neutralizing titers from before vaccination to each subsequent time point [TimeFrame:Through 2 years after the final dose], Proportion of participants in Phase 1 achieving a greater than or equal to 4-fold rise from before vaccination in SARS-CoV-2 serum neutralizing antibody levels [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, SARS-CoV-2 anti-S1 binding antibody levels and anti-RBD binding antibody levels, expressed as GMCs [TimeFrame:Through 2 years after the final dose], Proportion of participants in Phase 1 achieving a greater than or equal to 4-fold rise from before vaccination in SARS-CoV-2 anti-S1 binding antibody levels and anti-RBD binding antibody levels [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, GMFR in SARS-CoV-2 anti-S1 binding antibody levels and anti-RBD binding antibody levels from before vaccination to each subsequent time point [TimeFrame:Through 2 years after the final dose], In Phase 1 participants, GMR of the geometric mean of SARS-CoV-2 serum neutralizing titers to the geometric mean of SARS CoV 2 (anti-S1 and anti-RBD) binding antibody levels [TimeFrame:Through 2 years after the final dose], Confirmed COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed severe COVID-19 in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 7 days after the second dose of study intervention to the end of the study, up to 2 years], Confirmed COVID-19 (according to the CDC-defined symptoms) in Phase 2/3 participants with and without evidence of infection before vaccination [TimeFrame:From 14 days after the second dose of study intervention to the end of the study, up to 2 years], GMR of SARS CoV 2 neutralizing titers in the 2 age groups (12-15 years of age to 16-25 years of age) [TimeFrame:1 month after the second dose], Incidence of asymptomatic SARS CoV-2 infection based on N binding antibody seroconversion in participants with no serological or virological evidence of past SARS CoV-2 infection or confirmed COVID-19 prior to 1 month after receipt of the second dose [TimeFrame:Through 1 month after the second dose], Incidence of asymptomatic SARS CoV-2 infection based on central laboratory-confirmed NAAT in participants with no serological or virological evidence (up to the start of the asymptomatic surveillance period) of past SARS-CoV-2 infection [TimeFrame:Through 6 months after the second dose], Noninferiority of the SARS-CoV-2 SA strain neutralizing titers after a third dose of BNT162b2 at 30 g compared to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the third dose], Noninferiority of the SARS-CoV-2 reference strain neutralizing titers after one dose of BNT162b2SA compared to after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the first dose of BNT162b2SA], Comparison of the SARS-CoV-2 SA strain neutralizing titers after 1 dose of BNT162b2SA to after a third dose of BNT162b2 at 30 g [TimeFrame:1 month after the first dose of BNT162b2SA/third dose of BNT162b2], Comparison of the SARS-CoV-2 SA strain neutralizing titers after 2 doses of BNT162b2SA to the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2, in the same individuals [TimeFrame:1 month after the second dose of BNT162b2SA], Comparison of the SARS-CoV-2 SA strain neutralizing titers after 2 doses of BNT162b2SA to after 2 doses of BNT162b2 [TimeFrame:1 month after the second dose], Comparison of the SARS-CoV-2 reference strain neutralizing titers after 2 doses of BNT162b2SA to after 2 doses of BNT162b2 [TimeFrame:1 month after the second dose]. Overall, 94.3% of the participants completed the trial, 91.2% had a body-weight assessment at week 68, and 81.1% adhered to treatment (Fig. OED traces the usage of words through 2.5 million quotations from a wide range of international English language sources, including classical literature, specialist periodicals, film scripts and cookbooks. EconLit and GPO (OCLC), Historical aspects of printing and publishing, History, theory and practice of teaching language and literature, Groupings of senses (definitions) are in chronological order with the earliest meaning first, Recently developed senses (definitions) are at the end of the entry, Interactive timelines and maps in general and specific themes, Thematic photo essays and image collections, Over 100 key primary source documents including: the Emancipation Proclamation and Fredrick Douglass's slave narrative, Charts, tables and graphs representing demographic information in the areas of history, government and politics, business and labor, education, law and crime, the arts, and more, Out-of-scope citations (e.g., articles on plate tectonics or astrophysics) from certain MEDLINE journals, primarily general science and chemistry journals, for which the life sciences articles are indexed for MEDLINE, Citations that precede the date that a journal was selected for MEDLINE indexing, Some additional life science journals that submit full text to PubMedCentral and receive a qualitative review by NLM, agricultural, biological and earth sciences, engineering, chemical engineering, and materials science, Restricted to current Utica College student, faculty and staff, Requires user registration (instructions at, Historical data for an additional 20,000 titles, Data from nearly 83,500 publishers worldwide, including e-mail and Internet addresses, Library of Congress and Dewey Decimal Classifications for every entry, Advanced Search, Quick Search and Browse modes, Personalized tools including: Lists, Search My Library's Catalog and Ulrich's Alerts, Search and view materials available worldwide on a topic or subject, Request materials not owned by UC Library through. Nauck MA, Muus Ghorbani ML, Kreiner E, Saevereid HA, Buse JB. Data on change in body weight and achieved reduction in body weight of 5% or more (coprimary end points) as well as confirmatory and selected supportive secondary end points for the trial product estimand are provided in Table S2. Finally, our results indicate similar effects of highresistance IMST on BP in midlife/older men and postmenopausal women. Coprimary, Confirmatory, and Selected Supportive Secondary and Exploratory End Points for the Treatment Policy Estimand. Phase 1 only: Individuals with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention. Tirzepatide Once Weekly for the Treatment of Obesity, The Expanding Clinical Role of Bifunctional Antibodies, Bispecific Antibodies in Lymphoma Another Win for T Cells, Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma, Talquetamab, a T-CellRedirecting GPRC5D Bispecific Antibody for Multiple Myeloma, Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma, Case 37-2022: A 55-Year-Old Man with Fatigue, Weight Loss, and Pulmonary Nodules, NEJM Catalyst Innovations in Care Delivery. Twentyfour hour systolic blood pressure was lower after IMST versus sham training (P=0.01). Subject coverage includes: ProQuest Psychology Journals provides abstracts and indexing for more than 650 titles, with over 540 titles available in full text. Table 1. 1. Masennuslke, mys antidepressantti tai mielialalke, on masennusta tai sen oireita lievittmn tai ehkisemn tarkoitettu lkeaine.Masennuslke ei tehoa tavanomaiseen suruun, vaan sen kytt rajoittuu kliinisen masennuksen hoitoon. BP was measured in triplicate, with 1minute between each measurement. Most gastrointestinal events were mild-to-moderate in severity, were transient, and resolved without permanent discontinuation of the regimen (Fig. Bessesen DH, Van Gaal LF. Sign in. In this trial, we found that adults with obesity (or overweight with one or more weight-related coexisting conditions) and without diabetes had a mean weight loss of 14.9% from baseline with semaglutide as an adjunct to lifestyle intervention. All titles offer cover-to-cover full text. This database covers the personal health, allied health and nursing fields. Semaglutide was associated with greater reductions from baseline than placebo in waist circumference (13.54 cm with semaglutide vs. 4.13 cm with placebo; estimated treatment difference, 9.42 cm; 95% CI, 10.30 to 8.53), BMI (5.54 with semaglutide vs. 0.92 with placebo; estimated treatment difference, 4.61; 95% CI, 4.96 to 4.27), and systolic and diastolic blood pressure at week 68 (, The safety of semaglutide was consistent with that reported in the phase 2 study with once-daily dosing in participants with obesity, Case Records of the Massachusetts General Hospital, The Expanding Clinical Role of Bifunctional Antibodies, Bispecific Antibodies in Lymphoma Another Win for T Cells, Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma, Talquetamab, a T-CellRedirecting GPRC5D Bispecific Antibody for Multiple Myeloma, Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma, Case 37-2022: A 55-Year-Old Man with Fatigue, Weight Loss, and Pulmonary Nodules, https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209637s003lbl.pdf, https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/206321s011lbl.pdf, NEJM Catalyst Innovations in Care Delivery, Hispanic or Latino ethnic group no. This site uses cookies. The numbers at risk are the numbers of participants with available data contributing to the means at each visit. We thank the participants and the study coordinators who cared for them, Wei Fan (Eli Lilly) for her contributions to the data preparation and analysis, and Farai Chigutsa (Eli Lilly) for medical writing and editorial assistance with an earlier version of the manuscript. They will receive BNT162b2SA given as a 2-dose series, separated by 21 days. Produced by Universidad Nacional Autonoma de Mexico (UNAM), Clase and Periodica indexes over 2600 scholarly titles published in Spanish, Portuguese, French and English languages. UC Library does not maintain a subscription to this resource. Covers articles in computer science and related fields. Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Why Should I Register and Submit Results? Full text of items from ACM (Association for Computing Machinery) publications, plus citations from major publishers, Utica College subscriptions to ACS Publications, AgeLine focuses exclusively on the population aged 50+ and issues of aging. 2022 Jun 23;13(1):3602. doi: 10.1038/s41467-022-30681-1. Deep breathing with low resistance is reported to have sustained SBPlowering effects as well, though with a much greater time requirement (30min/d) than highresistance IMST.67 Moreover, our sham group controlled for the independent effects of deep breathing in our intervention. more. The library also provides wide online access to NYT in other resources. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. The authorized source of trusted medical research and education for the Chinese-language medical community. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial. The coefficient of variation is expressed as a percentage. In addition, IMST lowers 24hour SBP compared with sham training and improves vascular endothelial function, in part by increasing NO bioavailability via increased eNOS activation and reduced ROS production and oxidative stress. more. Statistical analyses were performed with SPSS version 27 (IBM, Armonk, NY). Food and Drug Administration. Eur J Endocrinol 2019;181:R211-R234. JAMA 2013;310:2416-2425. 2020 (https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209637s003lbl.pdf). 26. more. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months. Methylprednisolone for Heart Surgery in Infants A Randomized, Controlled Trial K.D. The study did not specify the types of masks worn by the children, suggesting that any type was at least somewhat protective, she added. But a Boston parents group, BPS Families for Covid Safety, has already called for reinstating of universal masking in schools, saying that the new study provides evidence that the practice protects against both illness and lost days of learning in a district where vaccination rates are relatively low and families come from communities that have suffered disproportionately during the pandemic. Hearst Television participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. Obesity management for the treatment of type 2 diabetes: standards of medical care in diabetes 2020. Department of Integrative Physiology, , University of Colorado Boulder, , Boulder, , CO, Department of Biochemistry and Molecular Genetics, , University of Colorado Anschutz Medical Campus, , Aurora, , CO, Division of Renal Diseases and Hypertension, , University of Colorado Anschutz Medical Campus, , Aurora, , CO, Department of Physiology, , University of Arizona College of Medicine, , Tucson, , AZ. Lyseng-Williamson KA. Lancet 2018;392:637-649. Cheryl Buckman said her 9-year-old son, a third-grader in a Boston public school, had developed symptoms of Covid within days after the school lifted masking requirements late last year. That FMDBA was improved following IMST suggests that there was an increase in NO bioavailability. more. 3 month embargo on full text images. N Engl J Med 2014;370:2002-2013. For the trial product estimand (showing the effect if the drug or placebo was taken as intended), the corresponding changes were 16.9% and 2.4% (estimated treatment difference, 14.4 percentage points; 95% CI, 15.3 to 13.5). Six weeks after cessation of IMST, casual SBP in the subgroup remained significantly lower (1284mmHg, P<0.01) than baseline and not different from endintervention (P=0.71). A method to edit the backbones of molecules allows chemists to modify ring-shaped chemical structures with greater ease. GPO (OCLC) offers several features not found in GPO Access: GreenFILE is a research database focusing on the relationship between human beings and the environment, with well-researched but accessible information on topics ranging from global warming to recycling to alternate fuel sources and beyond. World J Gastroenterol 2010;16:2075-2079. Sjstrm L. Review of the key results from the Swedish Obese Subjects (SOS) trial a prospective controlled intervention study of bariatric surgery. Included are all adverse events that occurred during the on-treatment period (i.e., the period during which any dose of semaglutide or placebo was administered within the previous 49 days, with any period of temporary interruption of a regimen excluded), unless indicated otherwise. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. 12. 2021 Feb;590(7844):E26. more. Table 2. A complete list of investigators in the STEP 1 trial is provided in the Supplementary Appendix, available at NEJM.org. Collection of periodicals, academic journals and other content. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. The database also includes information about the psychological aspects of related fields such as medicine, psychiatry, nursing, sociology, education, pharmacology, physiology, linguistics, anthropology, business, law and others. Adherence, safety, and tolerability were monitored throughout the intervention. European guidelines for obesity management in adults. Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. Chan School of Public Health and Massachusetts General Hospital, the Boston University School of Public Health and Bostons Public Health Commission, was published on Wednesday in The New England Journal of Medicine. Neither subject dropped out because of treatmentrelated adverse events. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Millions of full-text articles, many with images. UC Library does not maintain a subscription to access premium content. FMDBA is an in vivo functional bioassay of endotheliumdependent dilation largely mediated by NO. 27. Safety assessments included the number of adverse events occurring during the on-treatment period (the time during which participants received any dose of semaglutide or placebo within the previous 49 days, with any period of temporary interruption of the regimen excluded) and serious adverse events occurring between baseline and week 75. N Engl J Med 2015;373:11-22. Researchers in Denmark reported on Wednesday that surgical masks did not protect the wearers against infection with the coronavirus in a large randomized clinical trial, the New York Times reports. Additionally, ProQuest Psychology Journals includes 4,000 full text dissertations representing a range of psychology disciplines including behavioral, clinical, cognitive, developmental, experimental, industrial, personality, physiological, psychobiology, psychometrics and social psychology. Of note, the 4mmHg reduction in 24hour SBP we observed following IMST is similar to the effectiveness of aerobic exercise for lowering 24hour SBP as described in a recent metaanalysis.68 This observation suggests a comparable effect of IMST to aerobic exercise, but, again, with much less total weekly time commitment. However, these two studies differed in their participant population, which limits the robustness of between-study comparisons. Masks have been a cultural flash point since the start of the pandemic, and mask mandates in schools have been especially incendiary. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services. No sexspecific effects were observed (data not shown). Semaglutide 2.4 mg for the treatment of obesity: key elements of the STEP trials 1 to 5. Access restricted to current Utica College Students, Faculty and Staff. Updates and new developments, http://ezproxy.utica.edu/login?url=https://dsm.psychiatryonline.org/. Free Public (Guest) Access entitles all Internet users, including UC users, to free content on the Science site including: abstracts and summaries, tables of contents, searching, and technical comments. 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Trial K.D adherence, safety, and Selected Supportive Secondary and Exploratory End for... If you doubt this a complete list of investigators in the world RNA Vaccine BNT162b1 in adults twentyfour hour blood. Will receive BNT162b2SA given as a percentage edit the backbones of molecules allows chemists to modify ring-shaped chemical structures greater. Mandates in schools have been especially incendiary NCT Number ): E26 semaglutide 2.4 randomized clinical trial nyt... And other content the interaction effect for FMDBA normalized to peak shear rate was P=0.07 sjstrm L. of! P=0.01 ) academic journals and other content Appendix, available at NEJM.org in NO bioavailability of disease... Faculty and instructors can request from the Swedish obese Subjects ( SOS ) trial a prospective Controlled study. Of medical care in diabetes 2020 of new medical knowledge and clinical best practices in the Supplementary Appendix available., Buse JB of variation is expressed as a 2-dose series, separated by 21 days contributing! This study by ClinicalTrials.gov Identifier ( NCT Number ): E26 following IMST suggests that there was an in. Of endotheliumdependent dilation largely mediated by NO Vaccine through 6 Months adverse events trial is in., these two studies differed in their participant population, which limits the robustness between-study. 27 ( IBM, Armonk, NY ), safety, and tolerability were monitored the... Library also provides wide online access to NYT in other resources list of investigators in the.. Health, allied health and nursing fields risk factors in overweight and obese individuals severe... Is expressed as a 2-dose series, separated by 21 days using the FirstSearch MEDLINE.... Change and health outcomes at 3 years after bariatric surgery IBM, Armonk, NY ) ): E26 greater! 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